Some recent high-performance liquid chromatography separations of the enantiomers of pharmaceuticals and other compounds using the Whelk-O 1 chiral stationary phase
1997; Elsevier BV; Volume: 758; Issue: 1 Linguagem: Inglês
10.1016/s0021-9673(96)00569-9
ISSN1873-3778
AutoresChristopher J. Welch, Ted J. Szczerba, Scott R. Perrin,
Tópico(s)Chemical Synthesis and Analysis
ResumoThe Whelk-O 1 chiral stationary phase is generally useful for the chromatographic separation of the enantiomers of many classes of analytes including aryl propionic acid non-steroidal anti-inflammatory drugs, aryl epoxides, sulfoxides, alcohols, amides and esters. We herein report some additional recent enantioseparations obtained with this column, including a number of pharmaceuticals such as thalidomide, nicardipine, isradipine, mephenytoin, nirvanol, cyclandelate, bendroflumethiazide, bupivicaine, tolperisone, proglumide, tropicamide and indapamide. The separation of the enantiomers of a collection of additional analytes is also reported, including several compounds containing basic nitrogen, a heretofore difficult class of compounds to resolve with this column.
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