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High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients

2005; Wiley; Volume: 57; Issue: 5 Linguagem: Inglês

10.1002/ana.20462

1531-8249

Antonio Pisani, Filomena Fezza, Salvatore Galati, Natalia Battista, Simone Napolitano, Alessandro Finazzi‐Agrò, Giorgio Bernardi, Livia Brusa, Mariangela Pierantozzi, Paolo Stanzione, Mauro Maccarrone,

Neuroscience and Neuropharmacology Research

Annals of NeurologyVolume 57, Issue 5 p. 777-779 Letter High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients Antonio Pisani MD, Antonio Pisani MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorFilomena Fezza PhD, Filomena Fezza PhD Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", Rome, ItalySearch for more papers by this authorSalvatore Galati MD, Salvatore Galati MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorNatalia Battista PhD, Natalia Battista PhD Department of Biochemical Sciences, University of Teramo and Center of Experimental Neurobiology C. Mondino, Mondino-Tor Vergata-Santa Lucia, IRCSS, Rome, ItalySearch for more papers by this authorSimone Napolitano MD, Simone Napolitano MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorAlessandro Finazzi-Agrò MD, Alessandro Finazzi-Agrò MD Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", Rome, ItalySearch for more papers by this authorGiorgio Bernardi MD, Giorgio Bernardi MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorLivia Brusa MD, PhD, Livia Brusa MD, PhD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorMariangela Pierantozzi MD, Mariangela Pierantozzi MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorPaolo Stanzione MD, Paolo Stanzione MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorMauro Maccarrone MD, PhD, Mauro Maccarrone MD, PhD Department of Biochemical Sciences, University of Teramo and Center of Experimental Neurobiology C. Mondino, Mondino-Tor Vergata-Santa Lucia, IRCSS, Rome, ItalySearch for more papers by this author Antonio Pisani MD, Antonio Pisani MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorFilomena Fezza PhD, Filomena Fezza PhD Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", Rome, ItalySearch for more papers by this authorSalvatore Galati MD, Salvatore Galati MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorNatalia Battista PhD, Natalia Battista PhD Department of Biochemical Sciences, University of Teramo and Center of Experimental Neurobiology C. Mondino, Mondino-Tor Vergata-Santa Lucia, IRCSS, Rome, ItalySearch for more papers by this authorSimone Napolitano MD, Simone Napolitano MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorAlessandro Finazzi-Agrò MD, Alessandro Finazzi-Agrò MD Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", Rome, ItalySearch for more papers by this authorGiorgio Bernardi MD, Giorgio Bernardi MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorLivia Brusa MD, PhD, Livia Brusa MD, PhD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorMariangela Pierantozzi MD, Mariangela Pierantozzi MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorPaolo Stanzione MD, Paolo Stanzione MD Neurology Clinic, Department of Neuroscience, University of Rome "Tor Vergata" and Santa Lucia Foundation "Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalySearch for more papers by this authorMauro Maccarrone MD, PhD, Mauro Maccarrone MD, PhD Department of Biochemical Sciences, University of Teramo and Center of Experimental Neurobiology C. Mondino, Mondino-Tor Vergata-Santa Lucia, IRCSS, Rome, ItalySearch for more papers by this author First published: 25 April 2005 https://doi.org/10.1002/ana.20462Citations: 168Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Piomelli D. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 2003; 4: 873–884. 2 Giuffrida A, Leweke FM, Gerth CW, et al. Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. Neuropsychopharmacology 2004; 29: 2108–2114. 3 Gubellini P, Picconi B, Bari M, et al. Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. J Neurosci 2002; 22: 6900–6907. 4 Di Marzo V, Hill MP, Bisogno T, et al. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. FASEB J 2000; 14: 1432–1438. 5 Hurley MJ, Mash DC, Jenner P. Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain. J Neural Transm 2003; 110: 1279–1288. Citing Literature Volume57, Issue5May 2005Pages 777-779 ReferencesRelatedInformation