Produção Nacional
Revisado por pares
Chromosome 22q a frequent site of allele loss in head and neck carcinoma
2000; Wiley; Volume: 22; Issue: 6 Linguagem: Inglês
10.1002/1097-0347(200009)22
ISSN1097-0347
AutoresRegina Célia Poli‐Frederico, Nádia Aparecida Bérgamo, Patrícia P. Reis, Luiz Paulo Kowalski, Maria Zieleńska, Jeremy A. Squire, Sílvia Regina Rogatto,
Tópico(s)Sarcoma Diagnosis and Treatment
ResumoHead & NeckVolume 22, Issue 6 p. 585-590 Chromosome 22q a frequent site of allele loss in head and neck carcinoma Regina C. Poli-Frederico PhD, Regina C. Poli-Frederico PhD Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this authorNadia A. Bergamo PhD, Nadia A. Bergamo PhD Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this authorPatricia P. Reis MS, Patricia P. Reis MS Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this authorLuiz P. Kowalski MD, PhD, Luiz P. Kowalski MD, PhD A. C. Camargo Hospital, Sao Paulo, Sao Paulo, BrazilSearch for more papers by this authorMaria Zielenska PhD, Maria Zielenska PhD Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorJeremy A. Squire PhD, Jeremy A. Squire PhD Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, Ontario Cancer Institute, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, CanadaSearch for more papers by this authorSilvia R. Rogatto PhD, Corresponding Author Silvia R. Rogatto PhD rogatto@ibb.unesp.br Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilDepartment of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this author Regina C. Poli-Frederico PhD, Regina C. Poli-Frederico PhD Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this authorNadia A. Bergamo PhD, Nadia A. Bergamo PhD Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this authorPatricia P. Reis MS, Patricia P. Reis MS Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this authorLuiz P. Kowalski MD, PhD, Luiz P. Kowalski MD, PhD A. C. Camargo Hospital, Sao Paulo, Sao Paulo, BrazilSearch for more papers by this authorMaria Zielenska PhD, Maria Zielenska PhD Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorJeremy A. Squire PhD, Jeremy A. Squire PhD Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, Ontario Cancer Institute, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, CanadaSearch for more papers by this authorSilvia R. Rogatto PhD, Corresponding Author Silvia R. Rogatto PhD rogatto@ibb.unesp.br Department of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilDepartment of Genetics, IB-UNESP-Botucatu, Sao Paulo, BrazilSearch for more papers by this author First published: 08 August 2000 https://doi.org/10.1002/1097-0347(200009)22:6 3.0.CO;2-4Citations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background Loss of heterozygosity (LOH) correlates with inactivated tumor suppressor genes. LOH at chromosome arm 22q has been found in a variety of human neoplasms, suggesting that this region contains a tumor suppressor gene(s) other than NF2 important to tumorigenesis. The aim of this study was to evaluate the presence of LOH on chromosome 22q11.2-13 and determine whether there was a relationship between loss in this genomic region and tumor histologic parameters, anatomic site, and survival in patients with squamous cell carcinoma of the head and neck (HNSCC). Methods Fifty matched blood and HNSCC tumor samples taken at the time of surgical treatment were evaluated for LOH by use of four microsatellite markers mapping to 22q11.2-q13. Clinical information was available for all patients. The frequency and distribution of LOH was correlated with clinical (age, sex, use of tobacco and alcohol, site of primary tumor, clinical stage, adjuvant therapy and overall survival) and histologic parameters (histopathologic stage, tumor differentiation). Results LOH at 22q was found in 19 of 50 (38%) informative tumors. The respective incidence of allelic loss for the patients was as follows: 28% at D22S421, 10% at D22S277, 8% at D22S446, and 4% at D22S280. No statistical differences were apparent with a mean follow-up of 30 months. Laryngeal tumors showed a higher incidence of LOH compared with oral tumors. Conclusions These results suggest that the D22S277 locus may be closely linked to a tumor suppressor gene (TSG) and involved in upper aerodigestive tract carcinogenesis. In particular, laryngeal tumors may harbor another putative TSG on 22q11.2-q12.3 that may play a role in aggressive stage III/IV disease. © 2000 John Wiley & Sons, Inc. Head Neck 22: 585–590, 2000. Citing Literature Volume22, Issue6September 2000Pages 585-590 RelatedInformation
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