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Relationship Between the pH of the Diffusion L'Ayer and the Dissolution Rate of Furosemide

1991; Taylor & Francis; Volume: 17; Issue: 12 Linguagem: Inglês

10.3109/03639049109057316

1520-5762

A. F. Marals, J. G. van der Watt,

Analytical Chemistry and Chromatography

Sodium bicarbonate and ascorbic acid, both highly water-soluble materials, were used to modify the initial dissolution rate of furosemide from tablet formulations in various dissolution media. The observed differences in the initial dissolution rates of the drug have been correlated with changes in the pH of the diffusion layer brought about by the diluents. The initial dissolution rate of furosemide was shown to be dependent on and controlled by the pH of the diffusion layer while the bulk exerted only a secondary effect by controlling the magnitude of the pH-change through its buffer capacity.