Produção Nacional
Revisado por pares
Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle
2000; Elsevier BV; Volume: 74; Issue: 6 Linguagem: Inglês
10.1016/s0015-0282(00)01627-7
ISSN1556-5653
AutoresArtur Dzik, Geralyn Lambert‐Messerlian, Vicente Mário Izzo, Jonatas Borges Soares, José Aristodemo Pinotti, David B. Seifer,
Tópico(s)Assisted Reproductive Technology and Twin Pregnancy
ResumoObjective: To examine whether the magnitude of the rise in inhibin B levels after gonadotropin challenge is associated with subsequent response to ovarian stimulation during IVF.Design: Inhibin B serum levels after EFORT (exogenous follicle-stimulating hormone ovarian reserve test).Setting: Academic clinical practice.Patient(s): Serum samples from women who had undergone ovarian reserve screening with FSH in preparation for IVF. Thirteen of these women had a poor response in IVF (canceled cycle for low estradiol and/or no oocytes retrieved), and 19 had a good response (≥10 oocytes retrieved).Intervention(s): EFORT test.Main Outcome Measure(s): Baseline (day 3) serum E2 (bE2), FSH (bFSH), and inhibin B (bInhB) levels and inhibin B and E2 levels 24 hours after EFORT (ΔInhB and ΔE2).Result(s): The mean bInhB and ΔInhB levels were significantly higher in good vs. poor responders. The odds ratio of having a good response for women with a ΔInhB of 202 pg/mL was 51.8 times (95% CI = 6.1–1,244) the corresponding odds for women with a ΔInhB of 49 pg/mL. As expected, ΔE2 was also significantly higher in good vs. poor responders; however, combination of ΔE2 plus ΔInhB did not improve the odds for predicting IVF response.Conclusion(s): Our data suggest that ΔInhB after EFORT may provide a method for predicting ovarian response to hyperstimulation in a subsequent IVF cycle.
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