Immunopathogenesis and role of T cells in psoriasis
2007; Elsevier BV; Volume: 25; Issue: 6 Linguagem: Inglês
10.1016/j.clindermatol.2007.08.012
ISSN1879-1131
AutoresKamran Ghoreschi, Christina Weigert, Martin Röcken,
Tópico(s)Mast cells and histamine
ResumoPsoriasis is a T cell–dependent autoimmune disease of the skin and joints. Disease manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing either interferon-γ (Th1) or interleukin (IL)-17 (Th17). These Th1 and Th17 cells interact with dermal dendritic cells, macrophages, mast cells, and neutrophils. Together, they cause an inflammation that mainly involves interferon-γ, tumor necrosis factor, IL-8, IL-12, IL-17, IL-19, and IL-23. New therapeutics either are directed against T cells, tumor necrosis factor, and IL-12/IL-23 or deviate immune responses into a protective IL-4–dominated Th2 phenotype.
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