Pd(II)Cl2 Mediated Oxidative Cyclisation of Hydroxy-Vinylfurans to Lactols: Synthesis of Hagen's Gland Lactones
2000; Elsevier BV; Volume: 56; Issue: 19 Linguagem: Inglês
10.1016/s0040-4020(00)00099-5
ISSN1464-5416
AutoresHari Babu Mereyala, Rajendrakumar Reddy Gadikota, Kondepudi Sugnana Sunder, S. Shailaja,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoA concise synthesis of Hagen's gland lactones 3–6 by a chiron approach starting from d-mannose is described. Transformation of d-mannose to dihydroxy-vinylfuran 8 followed by Pd(II)Cl2 mediated oxidative cyclisation to obtain the tetrahydrofurofuran diol 7 constituted the key reaction in the total synthesis of 3–6.
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