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Use of Experimental Design for the Optimization of the Production of New Secondary Metabolites by Two Penicillium Species

2010; American Chemical Society; Volume: 73; Issue: 11 Linguagem: Inglês

10.1021/np100470h

1520-6025

Eli F. Pimenta, Aline Maria de Vita-Marques, Aristeu Gomes Tininis, Mirna Helena Regali Seleghim, Lara Durães Sette, Katyuscya Veloso, Antônio G. Ferreira, David E. Williams, Brian O. Patrick, Doralyn S. Dalisay, Raymond J. Andersen, Roberto G. S. Berlinck,

Fungal Biology and Applications

A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites.