Vasodilatory Effects of Lidocaine on Epicardial Porcine Coronary Arteries
1990; Karger Publishers; Volume: 41; Issue: 5 Linguagem: Inglês
10.1159/000138734
ISSN1423-0313
AutoresNeal Perlmutter, Richard Ashby Wilson, Scott Edgar, Wendy Sanders, Barry Greenberg, Ralph D. Tanz,
Tópico(s)Cardiovascular Disease and Adiposity
ResumoTo investigate the mechanism of lidocaine's effect to cause vasorelaxation, swine epicardial mid-right coronary arterial rings were placed under constant (5 g) tension in a muscle bath, precontracted with 35 mmol/l KCl and exposed to increasing concentrations of lidocaine (3–2,000 μg/ml). At a concentration of 10μg/ml, mild vasoconstriction occurred, increasing tension 1.9 ± 0.1 % above baseline. Vasodilation began to occur at 30 μg/ml and was maximal at 2,000 μg/ml, reducing tension 97.5 ± 0.2% below baseline. Vasodilation was not altered significantly by removal of endothelium or by pretreatment with propranolol or indometacin.
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