Correlation Between TGF-β1 and p21 (WAF1/CIP1) Expression and Prognosis in Resectable Invasive Ductal Carcinoma of the Pancreas
2001; Lippincott Williams & Wilkins; Volume: 22; Issue: 4 Linguagem: Inglês
10.1097/00006676-200105000-00002
ISSN1536-4828
AutoresKoji Hashimoto, Yoshinori Nio, Shoichiro Sumi, Tomoko Toga, Hiroshi Omori, Masayuki Itakura, Seiji Yano,
Tópico(s)Cancer-related Molecular Pathways
ResumoTransforming growth factor-beta1 (TGF-beta1) inhibits the growth of a variety of epithelial cells; however, in many types of tumors it loses its inhibitory effect. p21(WAF1/CIP1), one of the cyclin-dependent kinase (Cdk) inhibitors induced by TGF-beta1, is considered a downstream effector of the growth-inhibitory function of TGF-beta1. We assessed the clinicopathologic significance of TGF-beta1 and p21 expression in resectable invasive ductal carcinoma (IDC) of the pancreas. Immunohistochemical examination of the expression of TGF-beta1 and p21 in 62 patients revealed positive expression of TGF-beta1 in 28 (45%) and of p21 in 25 (40%) of the 62 patients, and a significant correlation between the two expressions. The survival curve of patients with TGF-beta1(+) tumors was significantly higher than that of patients with TGF-beta1(-) tumors; p21(+) patients showed a higher survival curve than did p21(-) patients, but the difference was not statistically significant. Simultaneous analysis of TGF-beta1 and p21 expression showed that the patients with TGF-beta1(+)/p21(+) tumors had a significantly better prognosis than the others. Multivariate analysis showed that TGF-beta1 was a significantly low risk factor for death due to IDC. The concurrent evaluation of TGF-beta1 and p21 expression would be an effective tool in the prediction of the prognosis of patients with pancreatic cancer.
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