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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Autologous Fat Grafting for Treatment of Breast Implant Capsular Contracture: A Study in Pigs

2014; Oxford University Press; Volume: 34; Issue: 5 Linguagem: Inglês

10.1177/1090820x14533184

ISSN

1527-330X

Autores

Guilherme Berto Roça, Ruth Graf, Renato da Silva Freitas, Guataçara Schenfelder Salles, Júlio César Francisco, Lúcia de Noronha, Ivan Maluf,

Tópico(s)

Tissue Engineering and Regenerative Medicine

Resumo

Capsular contracture (CC) is a common complication after breast augmentation. Autologous fat grafting may be effective for restoring tissue vascularization and function.The authors evaluated the efficacy of autologous fat grafting in a porcine model as a treatment for CC after breast augmentation.This prospective study was performed in 20 female 30-day-old pigs. Each animal was implanted with three 30-cc textured silicone implants (stage 1 of the experiment). Group A served as the untreated control group. To induce CC, 2 mL of autologous fibrin glue was applied to the pericapsular space in group B and C animals at implantation. Three months after implantation (stage 2), the CCs of all groups were assessed by Baker classification and applanation tonometry (AT). Liposuction was performed in group B to harvest fat for these animals. Three months after group B underwent fat grafting, all 3 groups were reevaluated. Reassessments included Baker classification, AT, histologic analysis, and tensiometry (stage 3).The deposition of mature and immature collagen was similar for the 3 groups. The amount of fat remaining around the implanted capsules did not differ significantly between the groups. At stage 3, group B exhibited significantly larger tonometry areas than did group C. The CCs in groups B and C were significantly thicker than those of group A, but the difference between groups B and C was not significant. Capsule rupture forces did not differ significantly between groups A and B but were significantly higher in group C compared with the other groups.Results in this animal model indicate that pericapsular lipoinjection may be a promising treatment for CC in humans.

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