Guided Antithrombotic Therapy: Current Status and Future Research Direction
2012; Lippincott Williams & Wilkins; Volume: 126; Issue: 13 Linguagem: Inglês
10.1161/circulationaha.112.105908
ISSN1524-4539
AutoresValentı́n Fuster, Deepak L. Bhatt, Robert M. Califf, Alan D. Michelson, Marc S. Sabatine, Dominick J. Angiolillo, Eric Bates, David J. Cohen, Barry S. Coller, Bruce Furie, Jean‐Sébastien Hulot, Kenneth G. Mann, Jessica L. Mega, Kiran Musunuru, Christopher J. O’Donnell, Matthew J. Price, David J. Schneider, Daniel I. Simon, Jeffrey I. Weitz, Marlene S. Williams, W. Keith Hoots, Yves Rosenberg, Ahmed Hasan,
Tópico(s)Heart Failure Treatment and Management
ResumoHomeCirculationVol. 126, No. 13Guided Antithrombotic Therapy: Current Status and Future Research Direction Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBGuided Antithrombotic Therapy: Current Status and Future Research DirectionReport on a National Heart, Lung and Blood Institute Working Group Valentin Fuster, MD, PhD, Deepak L. Bhatt, MD, MPH, Robert M. Califf, MD, Alan D. Michelson, MD, Marc S. Sabatine, MD, MPH, Dominick J. Angiolillo, MD, PhD, Eric R. Bates, MD, David J. Cohen, MD, MSc, Barry S. Coller, MD, Bruce Furie, MD, Jean-Sebastien Hulot, MD, PhD, Kenneth G. Mann, PhD, Jessica L. Mega, MD, MPH, Kiran Musunuru, MD, PhD, MPH, Christopher J. O'Donnell, MD, MPH, Matthew J. Price, MD, David J. Schneider, MD, Daniel I. Simon, MD, Jeffrey I. Weitz, MD, Marlene S. Williams, MD, W. Keith Hoots, MD, Yves D. Rosenberg, MD, MPH and Ahmed A.K. Hasan, MD, PhD Valentin FusterValentin Fuster From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Deepak L. BhattDeepak L. Bhatt From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Robert M. CaliffRobert M. Califf From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Alan D. MichelsonAlan D. Michelson From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Marc S. SabatineMarc S. Sabatine From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Dominick J. AngiolilloDominick J. Angiolillo From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Eric R. BatesEric R. Bates From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , David J. CohenDavid J. Cohen From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Barry S. CollerBarry S. Coller From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Bruce FurieBruce Furie From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Jean-Sebastien HulotJean-Sebastien Hulot From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Kenneth G. MannKenneth G. Mann From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Jessica L. MegaJessica L. Mega From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Kiran MusunuruKiran Musunuru From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Christopher J. O'DonnellChristopher J. O'Donnell From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Matthew J. PriceMatthew J. Price From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , David J. SchneiderDavid J. Schneider From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Daniel I. SimonDaniel I. Simon From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Jeffrey I. WeitzJeffrey I. Weitz From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Marlene S. WilliamsMarlene S. Williams From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , W. Keith HootsW. Keith Hoots From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). , Yves D. RosenbergYves D. Rosenberg From the Mount Sinai School of Medicine, New York, NY (V.F., J.-S.H.); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (V.F.); VA Boston Healthcare System, Boston, MA (D.L.B.); Brigham and Women's Hospital, Boston, MA (D.L.B., A.D.M., M.S.S., J.L.M., K.M.); Duke University Medical Center, Durham, NC (R.M.C.); Boston Children's Hospital, Boston, MA (A.D.M.); Harvard Medical School, Boston, MA (A.D.M., M.S.S., B.F., J.L.M., K.M.); University of Florida College of Medicine-Jacksonville, FL (D.J.A.); University of Michigan Health System, Ann Arbor, MI (E.R.B.); Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.); The Rockefeller University, New York, NY (B.S.C.); Beth Israel Deaconess Medical Center, Boston, MA (B.F.); University of Vermont, Burlington, VA (K.G.M., D.J.S.); Framingham Heart Study, Bethesda, MD (C.J.O.); National Heart, Lung, and Blood (NHLBI) Institute, National Institutes of Health, Bethesda, MD (C.J.O., W.K.H., Y.D.R., A.A.K.H.); Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.); University Hospitals Case Medical Center, Cleveland, OH (D.I.S.); McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Johns Hopkins Bayview Medical Center, Baltimore, MD (M.S.W.). and Ahmed A.K. HasanAhmed A.K. Hasan From the Moun
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