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Examination of a multiple dipole inverse cardiac generator, based on accurately determined model data

1973; Elsevier BV; Volume: 6; Issue: 3 Linguagem: Inglês

10.1016/s0022-0736(73)80033-0

1532-8430

Raymond E. Ideker, Daniel A. Brody, John W. Cox, Francis W. Keller,

Cardiac pacing and defibrillation studies

The multiple dipole array is a model of cardiac electrical activity whose elements are dipoles which are fixed in location and orientation to correspond to specific regions of the heart. The dipole moments are constrained to positive or zero values so that the dipoles always point outward from endocardium to epicardium. An array of this type was examined for its ability to reflect the dipole moments of each region of the “Coriolis” generator (a biventricular model of the electromotive forces of the canine heart). Dipole strengths of the array were calculated inversely from simulated surface potentials which would have been created by the Coriolis generator if it had been placed in a bounded, spherical, homogeneous medium. Although inversely computed dipole strengths of the original array represented dipole moments of regions of the right ventricle and septum of the Coriolis generator very poorly, a modified array indicated adequately the combined moments of these two structures. This modified array included within the same region portions of both the septum and the overlying right ventricle. The ability of the modified array to detect, locate, and quantify an increase or decrease in dipole moment of any portion of the Coriolis generator was excellent. However, when the angle between the actual dipole moment of a region and the array dipole representing that region was enlarged, the ability of the array to represent the Coriolis generator was greatly diminished.