New types of spin-labelled sugar and nucleoside analogs: Pyrrolidine, morpholine and piperidine N-Oxyls
1991; Elsevier BV; Volume: 32; Issue: 33 Linguagem: Inglês
10.1016/s0040-4039(00)79882-0
ISSN1873-3581
AutoresJean M. J. Tronchet, Guido Zosimo‐Landolfo, Mirna Balkadjian, Alessandra Ricca, Martina Zsély, Françoise Barbalat‐Rey, Daniel Cabrini, Patrick Lichtle, Michael Geoffroy,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoAnalogs of blocked furanose (20) or pyranose sugars (i.e. 15) and of nucleosides (i.e. 23) in which the ring oxygen has been replaced with a -N(OH)-bridge have been prepared in generally good yields by a general reductive cyclization procedure preserving the configuration of the preexistant asymetric centers and proceedings stereoselectively (in more favorable cases stereospecifically) when creating a new asymetric center. The title compounds oxidized to nitroxide free radicals affording usable ESR spectra.
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