Intra-arterial cisplatin with or without radiation in limb-sparing for canine osteosarcoma
1993; Wiley; Volume: 71; Issue: 8 Linguagem: Inglês
10.1002/1097-0142(19930415)71
ISSN1097-0142
AutoresStephen J. Withrow, Donald E. Thrall, Rodney C. Straw, B. E. Powers, R H Wrigley, Susan Μ. LaRue, Rodney L. Page, Daniel Richardson, K. W. Bissonette, C. W. Betts, David J. DeYoung, S. Richter, Vicki J. Jameson, Stephen L. George, R K Dodge, Edward L. Gillette, Evan B. Douple,
Tópico(s)Virus-based gene therapy research
ResumoMethods. Forty-nine dogs with spontaneously occurring osteosarcoma underwent limb-sparing surgery after preoperative therapy consisting of intra-arterial cisplatin alone or intra-arterial cisplatin in combination with doses of radiation from 20–40 Gy in 10 fractions. All resections were marginal, and the defect was repaired with a cortical allograft. Results. Local tumor control was strongly influenced by the percent necrosis in the excised specimen. Overall, the estimated 1-year local recurrence rate was approximately 32% (by life-table estimate). Dogs with less than 75% necrosis had an estimated 1-year recurrence rate of 65%; those with greater than 75% necrosis had an estimated 1-year recurrence rate of 15% (P = 0.004, by log-rank test). Local recurrence was influenced by the radiation dose. Dogs receiving 28 Gy or less had an estimated 50% 1-year recurrence rate, and those receiving 32 Gy or more had an estimated 8% 1-year recurrence rate (P = 0.03, by log-rank test). Normal host bone more frequently became necrotic at doses of 36 Gy or more. Conclusions. Intra-arterial cisplatin in combination with moderate doses of radiation (32 Gy) can achieve a high percent tumor necrosis while maintaining host bone viability. Survival was limited by distant metastasis but was lengthened by treatment compared with some earlier findings.
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