Portal de Periódicos da CAPES

Protease Injury in Airways Disease

1991; Wiley; Volume: 624; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1991.tb17026.x

1749-6632

Stephen I. Rennard, Kathleen Rickard, Joe D. Beckmann, GUILLERMO HUERTA, Sekiya Koyama, Richard Robbins, Debra J. Romberger, John R. Spurzem, Austin B. Thompson,

Vascular Anomalies and Treatments

In summary, proteases are present in the airway in inflammatory airways disease. These enzymes can damage the airway epithelium. As a consequence, airway function can be altered, and long-term changes in airway anatomy can result. Although the exact cellular and biochemical mechanisms that lead to these changes are incompletely described, it seems likely that they will play important roles in clinical airways disease. As such, these pathways may represent novel opportunities for therapeutic intervention.