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Frequencies of allele groups HLA ‐A, HLA ‐B and HLA ‐ DRB 1 in a population from the northwestern region of S ão P aulo S tate, B razil

2014; Wiley; Volume: 42; Issue: 1 Linguagem: Inglês

10.1111/iji.12159

1744-313X

Christiane Maria Ayo, Ana Vitória da Silveira Camargo, Denise Haddad Xavier, Mirella Fontana Batista, O Carneiro, Cinara Cássia Brandão de Mattos, Octávio Ricci, Luíz Carlos de Mattos,

Immunotherapy and Immune Responses

Summary The aim of this study was to estimate the HLA ‐ A , HLA ‐ B and HLA ‐ DRB 1 allele groups frequencies in a population of 1559 volunteer bone marrow donors from the northwestern region of S ão P aulo S tate grouped according to ethnicity. An additional objective was to compare the allele frequencies of the current study with data published for other B razilian populations. The allele groups were characterized by the PCR ‐r SSO method using L uminex ® technology. Twenty HLA ‐ A , 32 HLA ‐ B and 13 HLA ‐ DRB 1 allele groups were identified. The most common allele groups in E uropean descent and mixed A frican and E uropean descent samples were HLA ‐ A *02, HLA ‐ B *35 and HLA ‐ DRB 1*13, while HLA ‐ A *02, HLA ‐ B *35 and HLA ‐ DRB 1*11 were more common in A frican descent samples. The HLA ‐ A *23, HLA ‐ A *36, HLA ‐ B *58 and HLA ‐ B *81 allele groups were more common in sample from African descent than European descent, and the HLA ‐ DRB 1*08 was more common in mixed A frican and E uropean descent than in E uropean descent. Allele group frequencies were compared with samples from other B razilian regions. The HLA ‐ A *30 and HLA ‐ A *23 were more common in this study than in the populations of R io G rande do S ul and P araná; and the HLA ‐ A *01, HLA ‐ B *18, HLA ‐ B *57 and HLA ‐ DRB 1*11 were more common in this study than in the population of P iauí. The least frequent allele groups were HLA ‐ A *31, HLA ‐ B *15, HLA ‐ B *40 and HLA ‐ DRB 1*08 for the population of P iauí, HLA‐A*01 and HLA ‐ A *11 for P arana, HLA ‐ A *02 and ‐ A *03 for R io G rande do S ul and HLA ‐ DRB 1*04 for P araná, R io G rande do S ul and P iauí. These data provide an overview on the knowledge on HLA diversity in the population of the northwestern region of S ão P aulo S tate and show that the genes of this system are useful to distinguish different ethnic groups.