Selective antagonism of prostaglandin (PG) E1, PGD2 and prostacyclin (PGI2) on human and rabbit platelets by DI-4-phloretin phosphate (DPP)
1978; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês
10.1016/0049-3848(78)90053-1
ISSN1879-2472
Autores Tópico(s)Antiplatelet Therapy and Cardiovascular Diseases
ResumoThe inhibition of human and rabbit platelet aggregation by prostaglandin (PG) E1, PGD2 and prostacyclin (PGI2) was examined to determine if the three PGs inhibit platelets via a common receptor. Di-4-phloretin phosphate (DPP) was found to antagonise PGD2, but not PGE1 or PGI2 on human platelets. In contrast, on rabbit platelets, DPP antagonised PGI2 and PGE1 but not PGD2. The results suggest that there are two distinct types of PG receptors on human and rabbit platelets activated either by prostacyclin or PGD2.
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