A versatile route to β-enamino esters by acylation of lithium enamines with diethyl carbonate or benzyl chloroformate
1995; Elsevier BV; Volume: 51; Issue: 31 Linguagem: Inglês
10.1016/0040-4020(95)00476-o
ISSN1464-5416
AutoresGiuseppe Bartoli, Cristina Cimarelli, Renato Dalpozzo, Gianni Palmieri,
Tópico(s)Synthesis and Characterization of Pyrroles
ResumoA versatile route to β-enamino esters 1, using accessible starting materials, was developed. Lithiated enamines are allowed to react with diethyl carbonate or benzyl chloroformate with the formation of the β-enamino esters 1a or 1b. The reaction is rather general from a wide array of ketimines and aldimines. Products included cyclic β-enamino esters 1aa-ac, very useful for the synthesis of natural products.
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