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Compostos organofosforados pentavalentes: histórico, métodos sintéticos de preparação e aplicações como inseticidas e agentes antitumorais

2007; Brazilian Chemical Society; Volume: 30; Issue: 1 Linguagem: Inglês

10.1590/s0100-40422007000100028

ISSN

1678-7064

Autores

Viviane Martins Rebello dos Santos, Cláudio Luis Donnici, João Batista Neves DaCosta, Janaína Marques Rodrigues Caixeiro,

Tópico(s)

Organophosphorus compounds synthesis

Resumo

ANTITUMOR AGENTS.This paper is a review of the history, synthesis and application of organophosphorus compounds, especially of those of pentavalent phosphorus, such as phosphoramidates, phosphorothioates, phosphonates and phosphonic acids with insecticide and anticancer activities.The organophosphorus compounds with agrochemical applications show great structural variety, They include not only insecticides, but also fungicides, herbicides, and others.The large variety of commercially available organophosphorus pesticides is remarkable.Even more interesting is the high efficiency of some organophosphorus compounds as anticancer agents such as cyclophosphamide and its derivatives.

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