The roles of CD8 in cytotoxic T lymphocyte function
1993; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês
10.1016/0167-5699(93)90283-q
ISSN1355-8242
AutoresAnne M. O’Rourke, Matthew F. Mescher,
Tópico(s)Cell Adhesion Molecules Research
ResumoThe CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.
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