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BIBTEX RIS

Effect of tripanosomicide benznidazole (Rochagan®) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats

2008; Instituto de Tecnologia do Paraná (Tecpar); Volume: 51; Issue: spe Linguagem: Inglês

10.1590/s1516-89132008000700028

ISSN

1678-4324

Autores

Vanessa Santos de Arruda Barbosa, Maria de Carvalho Xavier Holanda, Roseane Pereira da Silva, Daniel Pereira de Oliveira, Maurício Ferreira da Silva Júnior, Elias Herculano de Oliveira, Maria Helena Constantino Spyrides, Aldo Cunha Medeiros,

Tópico(s)

Parasites and Host Interactions

Resumo

Benznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas' disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole.

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