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Intramuscular manifestation of non-hodgkin lymphoma and myeloma: Prevalence, clinical signs, and computed tomography features

2010; SAGE Publishing; Volume: 51; Issue: 1 Linguagem: Inglês

10.3109/02841850903296678

1600-0455

Alexey Surov, Hans-Jürgen Holzhausen, Dirk Arnold, Jörg Schmidt, Rolf‐Peter Spielmann, Curd Behrmann,

Multiple Myeloma Research and Treatments

Intramuscular manifestations of malignant immunoproliferative diseases (IMMID) are very rare.To determine the prevalence and the clinical features of IMMID in a large series of patients, and to analyze their radiological appearances.Between 1997 and 2007, 20 patients with IMMID (non-Hodgkin lymphoma [NHL], n=14, and myeloma, n=6) were identified. All patients underwent computed tomography (CT). In five cases, magnetic resonance imaging (MRI) was additionally performed.Clinically, 16 patients presented with local pain and soft-tissue swelling. In four patients, IMMID was found incidentally. The most common site was the erector spinae muscle, followed by the iliopsoas and pelvic muscles. In 13 cases of IMMID, diffuse mass-forming muscle infiltration was found. Focal intramuscular masses were identified in seven cases.NHL mostly manifests as diffuse muscle enlargement, whereas myelomas form focal intramuscular masses. Nevertheless, CT and MR appearances are nonspecific and can be misinterpreted as muscle sarcoma or inflammatory disease. Although rare, muscle involvement should be considered in the differential diagnosis of muscle disorders in patients with non-Hodgkin lymphoma and myeloma.