Model studies for the synthesis of galbonolide B
2005; Royal Society of Chemistry; Volume: 3; Issue: 16 Linguagem: Inglês
10.1039/b505378a
ISSN1477-0539
AutoresJames J. Eshelby, Matthias Goessman, Philip J. Parsons, Lewis E. Pennicott, Adrian J. Highton,
Tópico(s)Enzyme Catalysis and Immobilization
ResumoThe construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of 1 has been constructed using an ester enolate rearrangement/silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/mercury assisted ring closure protocol.
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