Mesenchymal-Cel Proliferation in Liver Disease of the Alcoholic
1964; American Medical Association; Volume: 187; Issue: 8 Linguagem: Inglês
10.1001/jama.1964.03060210048011
ISSN1538-3598
AutoresCarroll M. Leevy, Willem tenHove, Maceo M. Howard,
Tópico(s)Liver physiology and pathology
ResumoAVAILABLE INFORMATION suggests that ethanol-induced hepatic necrosis in the setting of fatty liver initiates a regenerative reaction which ultimately leads to lobular distortion and cirrhosis. 1 Further research is now desirable to elucidate mechanisms responsible for the hepatic cell damage, to discover initiating and controlling factors in regeneration, and to determine the contribution of various cell types to liver repair. The present investigation was undertaken to delineate the degree, localization, and effect of cellular proliferation which accompanies liver injury due to alcoholism. Autoradiographic techniques employing tritiated thymidine (H 3 T) were utilized 2 to evaluate the influence of ethanol intoxication on hepatic deoxyribonucleic acid (DNA) synthesis and regeneration in experimental animals and man. Materials and Methods Animal experiments were conducted to determine the effect of acute ethanol intoxication on hepatic DNA synthesis. A single or divided oral dose of 0.6 gm of ethanol per 100 gm weight, each day for 3
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