Analysis of sequence‐dependent curvature in matrix attachment regions
2001; Wiley; Volume: 489; Issue: 2-3 Linguagem: Inglês
10.1016/s0014-5793(01)02098-1
ISSN1873-3468
Autores Tópico(s)Animal Genetics and Reproduction
ResumoSequence‐dependent DNA conformations of matrix attachment regions (MARs) available in a database were calculated using the wedge model, and compared with randomly chosen genes, promoters, enhancers and transposons. The MARs had a longer bent part and higher angle/helical turn than the other regions. It is known that some MAR sequences have A‐tracts that cause DNA bending, and we also found many A‐tracts in examined MARs. Furthermore, non‐random and clustered distribution of A‐tracts shown here gave further evidence of the importance of A‐tracts for MAR conformations. These results suggest that DNAs of MARs have a characteristic conformation instead of conserved sequence.
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