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Myasthenia and Prostaglandin E_1

1979; American College of Physicians; Volume: 90; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-90-4-719_1

1539-3704

David F. Horrobin,

Blood disorders and treatments

Letters and Corrections1 April 1979Myasthenia and Prostaglandin E1DAVID F. HORROBIN, M.A., D.PHIL., B.M.DAVID F. HORROBIN, M.A., D.PHIL., B.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-4-719_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I was interested in the report of a myastheriialike syndrome induced by penicillamine (1) in the December 1978 issue. The rapid onset and reversal were particularly striking.My group has recently shown that penicillamine stimulates the formation of material with the properties of prostaglandin E1 (2, 3). Prostaglandin E1 infusion into humans rapidly produces subjective and objective muscle weakness, reversed on stopping the infusion. There is some evidence that an allosteric site at the acetyl choline receptor on the electric organ may be occupied by a prostaglandin (4).Prostaglandin E1seems to be a highly potent stimululator...References1. ATCHESONWARD SJ: Ptosis and weakness after start of D-penicillamine therapy. Ann Intern Med 89:939-940, 1978 LinkGoogle Scholar2. CUNNANEZINNERHORROBINMANKU SHDM: Copper inhibits responses to noradrenaline but not potassium. Interactions with prostaglandins E1, E(q), I, and penicillamine. Can J Physiol Pharmacol, in press. Google Scholar3. HORROBIN D: Prostaglandins: Physiology, Pharmacology and Clinical Significance. Montreal, Eden Press, 1978, p. 144 Google Scholar4. HORROBINMANKUALLYMORGANKARMALI DMARR: Quinacrine as a prostaglandin antagonist. Biochem Biophys Res Comm 76:1188-1193, 1977 CrossrefMedlineGoogle Scholar5. ZURIER R: Prostaglandins, inflammation and immune responses. Prostaglandins Ther 5:1-2, 1979 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Institut de Recherches Cliniques de Montréal Montréal, PQ H2W 1R7, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMiastenia grave induzida por D-penicilamina em paciente com esclerose sistêmica progressivaPenicillamine-induced myasthenia gravis in progressive systemic sclerosisMyotonic dystrophy: A disease caused by functional zinc deficiency due to an abnormal zinc-binding ligand? 1 April 1979Volume 90, Issue 4Page: 719-719KeywordsMusclesProstaglandin Issue Published: 1 April 1979 PDF DownloadLoading ...