Portal de Periódicos da CAPES

Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus

2013; Elsevier BV; Volume: 101; Linguagem: Inglês

10.1016/j.antiviral.2013.10.014

1872-9096

Raphaële Germi, Clara Mariette, Sophie Alain, Julien Lupo, Anne Thiébaut, Jean‐Pierre Brion, Olivier Épaulard, C. Saint Raymond, Paolo Malvezzi, Patrice Morand,

Toxoplasma gondii Research Studies

Cytomegalovirus (CMV) strains resistant to ganciclovir, cidofovir and/or foscarnet were genotypically and phenotypically characterised in two haematopoietic stem cell transplant recipients and three solid-organ transplant recipients with CMV disease. The anti-malaria drug artesunate led to a favourable virological and clinical response in three cases with mild CMV diseases (fever and neutropaenia) but was ineffective in two fatal CMV diseases with lung involvement in spite of a decrease in the CMV DNA load in blood and bronchoalveolar fluid.