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Metabolic balance studies in primary renal tubular acidosis: Effects of acidosis on external calcium and phosphorus balances

1966; Elsevier BV; Volume: 69; Issue: 4 Linguagem: Inglês

10.1016/s0022-3476(66)80048-3

1097-6833

Abby J. Greenberg, Helen McNamara, Wallace W. McCrory,

Neonatal Health and Biochemistry

The relationship between acidosis and calcium metabolism was investigated in a 4-year-old child with primary renal tubular acidosis uncomplicated by either skeletal changes or renal insufficiency. The results of metabolic balance studies obtained from an initial period of complete correction of the acidosis through the development of acidosis by cessation of alkali therapy and during the subsequent correction of the acidosis indicate that metabolic acidosis is associated with a negative calcium balance. An altered intestinal transport of calcium was found to be the major factor responsible for the negative calcium balance. Complete correction of the acidosis resulted in restoration of a positive calcium balance. The relationship between acidosis and calcium metabolism was investigated in a 4-year-old child with primary renal tubular acidosis uncomplicated by either skeletal changes or renal insufficiency. The results of metabolic balance studies obtained from an initial period of complete correction of the acidosis through the development of acidosis by cessation of alkali therapy and during the subsequent correction of the acidosis indicate that metabolic acidosis is associated with a negative calcium balance. An altered intestinal transport of calcium was found to be the major factor responsible for the negative calcium balance. Complete correction of the acidosis resulted in restoration of a positive calcium balance.