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Significance of Helicobacter pylori vacA intermediate region genotyping—a Bulgarian study

2012; Elsevier BV; Volume: 74; Issue: 3 Linguagem: Inglês

10.1016/j.diagmicrobio.2012.07.008

1879-0070

Daniel Yordanov, Lyudmila Boyanova, Rumyana Markovska, Galina Gergova, Ivan Mitov,

Galectins and Cancer Biology

The significance of the intermediate (i) region of the Helicobacter pylori vacA gene as a virulence factor associated with the severity of gastric disease is still disputable. The aim of the present study was to evaluate the prevalence and significance of vacA i alleles alone or in combination with other vacA alleles in symptomatic Bulgarian patients and to find out possible associations between vacA i genotype and patients' disease, age, sex, and other H. pylori virulence factors. Unlike vacA s1 and m1, vacA i1 prevalence was significantly higher (75.0%) in strains from peptic ulcer patients than in strains from nonulcer patients with gastric diseases (58.6%) (P = 0.022). Less virulent vacA s1 i2 m2 strains were more prevalent in females (P = 0.03), and cagA+ was associated with vacA i1, s1, m1, and their combinations. In conclusion, vacA i status is a better predictor for the strain virulence than other vacA alleles.