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KIM127, an Antibody that Promotes Adhesion, Maps to a Region of CD18 that Includes Cysteine-Rich Repeats

1995; Taylor & Francis; Volume: 3; Issue: 5 Linguagem: Inglês

10.3109/15419069509081292

2573-0029

Paul E. Stephens, Justyna T. Romer, Mari Spitali, Anthony Shock, Susan Ortlepp, Carl G. Figdor, M K Robinson,

Peptidase Inhibition and Analysis

A series of fusion proteins have been generated between human and mouse CD18. These proteins have been used to carry out preliminary mapping studies on a number of anti-CD18 antibodies including KIM127 an antibody that promotes CD18-dependent adhesion. This antibody maps to a region of the CD18 molecule between amino acids 406 and 570 in a region containing cysteine-rich repeats.