Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Stereoselective synthesis of selenosteroids

2010; Elsevier BV; Volume: 51; Issue: 17 Linguagem: Inglês

10.1016/j.tetlet.2010.02.090

1873-3581

Oscar E. D. Rodrigues, Diego de Souza, Letiére C. Soares, Luciano Dornelles, Robert A. Burrow, Helmóz R. Appelt, Camila Fillipi dos Santos Alves, Diego Alves, Antônio L. Braga,

Organic Chemistry Cycloaddition Reactions

A stereoselective synthesis of selenosteroids 4 and 5 has been achieved. Starting from commercial available cholesterol 1, followed by asymmetric epoxidation, and subsequently, by stereoselective epoxide ring opening, employing a selenium nucleophilic species, the correspondent products were afforded in high yields. The compounds were being evaluated for their biological activity and as a chiral pool for asymmetric transformations.