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Hypoglycemic properties of taurine: Not mediated by enhanced insulin release

1984; Elsevier BV; Volume: 33; Issue: 18 Linguagem: Inglês

10.1016/0006-2952(84)90204-1

1873-2968

Elliott C. Kulakowski, Joseph M. Maturo,

Cannabis and Cannabinoid Research

Taurine (2-aminoethanesulfonic acid) has been shown to be a potent hypoglycemie agent in the Wistar Kyoto rat (WKY). Glucose and insulin levels were measured in serum at various times after glucose loading (400 mg/kg, i.p.). Pretreatment with taurine (200 mg/kg, i.p.) attenuated the rise in serum glucose levels at 0.5 hr after glucose administration. In addition, taurine also prevented the rise in serum immunoreactive insulin levels. The taurine analogue hypotaurine produced a similar inhibition in the rise of both serum glucose and insulin levels while β-alanine, the car☐ylic acid derivative of taurine, was totally ineffective. The enhanced glucose clearance can be explained by an increase in deoxyglucose accumulation in skeletal muscle and liver. In the liver, a 50% increase in glycogen synthesis was observed. A possible interrelationship between taurine and insulin receptor is discussed.