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Slow Absorption of Conjugated Linoleic Acid in Rat Intestines, and Similar Absorption Rates of 9 c ,11 t -Conjugated Linoleic Acid and 10 t ,12 c -Conjugated Linoleic Acid

2007; Oxford University Press; Volume: 71; Issue: 8 Linguagem: Inglês

10.1271/bbb.70238

1347-6947

T. Tsuzuki, Ikuo Ikeda,

Cholesterol and Lipid Metabolism

We have previously shown that the 9c,11t-conjugated linoleic acid (CLA) concentration was always significantly higher than the 10t,12c-CLA concentration following the administration of these compounds to mice and rats, and considered that structural differences between the conjugated double bonds in these isomers affected absorption in the small intestine. This study investigates the absorption of CLA in the rat intestine by a lipid absorption assay of lymph from the thoracic duct. In Study 1, we used safflower oil and a triacylglycerol form of CLA (CLA-TG), while in Study 2, we used 9c,11t-CLA and 10t,12c-CLA. The cumulative recovery of CLA was lower than that of linoleic acid until two hours after sample administration. There was no difference in the extent of lymphatic recovery of 9c,11t-CLA and 10t,12c-CLA after the administration of CLA-TG, 9c,11t-CLA, and 10t,12c-CLA to the rats, suggesting that geometrical and positional isomerism of the conjugated double bonds did not influence the absorption.