METABOLISM OF THE STERIOD HORMONES, METABOLISM OF PROGESTERONE AND RELATED STEROIDS 1
1951; Oxford University Press; Volume: 49; Issue: 4 Linguagem: Inglês
10.1210/endo-49-4-440
ISSN1945-7170
AutoresFrank Ungar, Ralph I. Dorfman, Robert M. Stecher, Paul J. Vignos,
Tópico(s)Estrogen and related hormone effects
ResumoPREVIOUSin vivo studies in humans have indicated that progesterone may be reduced to and excreted as pregnanediol-3(α),20(α) (Venning and Browne, 1937; Buxton and Westphal, 1938; Hamblen et al., 1940; Dorfman et al., 1948) and pregnanol-3(α)-one-3 (Dorfman et al., 1948; Venning, 1947). We have now been able to show that allopregnanediol-3(α),20(α) is also a metabolite of progesterone. Some theoretical intermediates between progesterone and the saturated diols have also been investigated. Among these are pregnanedione-3,20 and allopregnanedione-3,20. Pregnanedione-3,20 was shown to be converted to pregnanediol-3(α),20(α) while allopregnanedione-3,20 was converted to allopregnane-diol-3(α),20(a:) as well as allopregnanediol-3(β),20(α). As a final part of this study Δ5-pregenol-3(β)-one-20, which has been isolated from hog testes (Ruzicka and Prelog, 1943; Haines et al., 1948) was studied in women. Previously Pearlman and Pincus (1946) reported the conversion of pregnenolone to pregnanediol-3(α),20(α) in a man and in a rabbit.
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