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Antiangiogenic therapy

2004; Cell Press; Volume: 6; Issue: 6 Linguagem: Inglês

10.1016/j.ccr.2004.12.003

1878-3686

Michelle I. Lin, William C. Sessa,

Cancer, Hypoxia, and Metabolism

Antiangiogenic therapy for solid tumors clearly destroys tumor vasculature and reduces tumor growth. As an unexpected bonus, drugs that neutralize VEGF signaling generate a "normalization window" for tumor vasculature. This occurs via the recruitment of pericytes to the tumor vasculature, an effect associated with the transient stabilization of vessels and improved oxygen delivery to hypoxic zones. The normalization process is mediated by angiopoietin-1 and matrix metalloproteinases and creates a window of opportunity for improved sensitivity to ionizing radiation and the delivery of chemotherapeutic drugs.