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Adriamycin in localized and metastatic uterine sarcomas

1979; Wiley; Volume: 12; Issue: 3 Linguagem: Inglês

10.1002/jso.2930120310

1096-9098

M.Steven Piver, Joseph J. Barlow, Shashikant Lele, R Yazigi,

Polymer Nanocomposite Synthesis and Irradiation

Abstract Seventeen women with metastatic uterine sarcomas were treated with Adriamycin chemotherapy. Only one (6%) had an objective response. In addition, 12 patients with early uterine sarcomas were randomized to Adriamycin versus no adjuvant chemotherapy in order to evaluate the effect of Adriamycin in reducing the incidence of subsequent distant recurrences. Of those women receiving Adriamycin, two developed distant metastasis and two developed life‐threatening congestive heart failure. Also, two of the six women who did not receive Adriamycin developed distant metastasis. Therefore, continuation of the randomized trial was considered unjustified.