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CYTOCHEMICAL EVIDENCE FOR THE CESSATION OF HORMONE PRODUCTION IN THE ZONA GLOMERULOSA OF THE RAT’S ADRENAL CORTEX AFTER PROLONGED TREATMENT WITH DESOXYCORTICOSTERONE ACETATE1

1947; Oxford University Press; Volume: 40; Issue: 6 Linguagem: Inglês

10.1210/endo-40-6-417

1945-7170

Roy O. Greep, Helen Wendler Deane,

Hormonal and reproductive studies

COMBINED morphological and cytochemical studies have revealed that the zona fasciculata of the adrenal cortex may atrophy, become hyperactive, or become exhausted without any conspicuous alteration in the zona glomerulosa (Deane and Greep, 1946; Deane and McKibbin, 1946; Deane and Shaw, 1947). The interpretation placed on these findings is that the adrenal cortex is composed of two separate secreting zones which produce different types of cortical hormones. Evidence obtained from physiological, chemical, and morphological studies of the adrenal cortex has suggested the dual nature of this gland.