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Foreign Body Reaction to Hyaluronic Acid (Restylane): An Adverse Outcome of Lip Augmentation

2006; Elsevier BV; Volume: 64; Issue: 8 Linguagem: Inglês

10.1016/j.joms.2006.04.028

1531-5053

Paul C. Edwards, John E Fantasia, Robert Iovino,

Dermatologic Treatments and Research

Nonanimal source hyaluronic acid (Restylane; Q-Medical Corporation, Uppsala, Sweden) is a relatively new redefining dermal filler that is being employed with increasing frequency in the fields of dermatology and cosmetic/facial plastic surgery. We report a case of a 74-year-old woman who presented with a firm submucosal nodule of the lower lip, which clinically was thought to represent a benign neoplasm. An excisional biopsy showed the presence of multiple cyst-like vacuolated areas surrounded by granulomatous tissue composed predominantly of histiocytes and foamy macrophages, consistent with a foreign body reaction. Subsequent to the pathology findings, the patient acknowledged that she had received injections of Restylane to the lips approximately 6 months before discovering the nodule. She had not mentioned this to her dentist or oral and maxillofacial surgeon to whom she had been referred because she believed that these 2 events were not related. Although hyaluronic acid-based dermal fillers reportedly have a low incidence of long-term side effects, clinicians should be aware of the possible development of foreign body reactions to these injectable agents. Discussion: Foreign Body Reaction to Hyaluronic Acid: An Adverse Outcome of Lip AugmentationJournal of Oral and Maxillofacial SurgeryVol. 64Issue 8PreviewI commend these authors for this timely article concerning foreign body reactions after the administration of facial fillers. Although this complication occurs infrequently, it is important that oral and maxillofacial surgeons and dentists be aware of the potential for granuloma formation and include this in their diagnostic acumen. Full-Text PDF