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Prevalence of benzocaine and lidocaine patch test sensitivity in Denmark: temporal trends and relevance

2011; Wiley; Volume: 65; Issue: 2 Linguagem: Inglês

10.1111/j.1600-0536.2010.01858.x

1600-0536

Jacob P. Thyssen, Kåre Engkilde, Torkil Menné, Jeanne D. Johansen,

Dermatology and Skin Diseases

Contact DermatitisVolume 65, Issue 2 p. 76-80 Prevalence of benzocaine and lidocaine patch test sensitivity in Denmark: temporal trends and relevance Jacob P. Thyssen, Corresponding Author Jacob P. Thyssen Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkJacob Pontoppidan Thyssen, Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, Ledreborg Allé 40, 1, 2820 Gentofte, Denmark. Tel: +45 3977 7307; Fax: +45 3977 7118. E-mail: [email protected]Search for more papers by this authorKåre Engkilde, Kåre Engkilde Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkSearch for more papers by this authorTorkil Menné, Torkil Menné Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkSearch for more papers by this authorJeanne D. Johansen, Jeanne D. Johansen Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkSearch for more papers by this author Jacob P. Thyssen, Corresponding Author Jacob P. Thyssen Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkJacob Pontoppidan Thyssen, Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, Ledreborg Allé 40, 1, 2820 Gentofte, Denmark. Tel: +45 3977 7307; Fax: +45 3977 7118. E-mail: [email protected]Search for more papers by this authorKåre Engkilde, Kåre Engkilde Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkSearch for more papers by this authorTorkil Menné, Torkil Menné Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkSearch for more papers by this authorJeanne D. Johansen, Jeanne D. Johansen Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, DK-2900 Hellerup, DenmarkSearch for more papers by this author First published: 13 January 2011 https://doi.org/10.1111/j.1600-0536.2010.01858.xCitations: 15 Conflicts of interest: The authors have declared no conflicts. Funding: None. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background. Allergens included in the European baseline series should result in positive patch test reactions in at least 1% of a patch test population. Inclusion of local anaesthetics other than benzocaine in the baseline series has previously been debated. Objectives. To investigate temporal trends of benzocaine and lidocaine allergy in dermatitis patients who underwent routine patch testing in a tertiary referral patch test centre, and to clarify and discuss whether lidocaine and benzocaine should be included in routine series. Methods. Dermatitis patients who underwent routine patch testing with benzocaine as a part of the European baseline series between 1985 and 2010 (n = 19 347) and dermatitis patients who underwent routine patch testing with lidocaine between 1994 and 2001 (n = 6265) and between 2007 and 2009 (n = 1360) were included. Results. The overall prevalences of contact allergy were 0.5% (benzocaine), 0.3% (lidocaine for the period 1994–2001), and 0.14% (lidocaine for the period 2007–2009). Current relevance was observed in 10% of those with benzocaine allergy and in 5% of those with lidocaine allergy. Conclusions. Benzocaine and lidocaine allergy is infrequent in Danish dermatitis patients. Lidocaine should only be used for aimed testing, and benzocaine should be removed from the baseline series used in Denmark. References 1 Thyssen J P, Menné T, Elberling J, Plaschke P, Johansen J D. Hypersensitivity to local anaesthetics – update and proposal of evaluation algorithm. Contact Dermatitis 2008: 59: 69–78. 2 Fisher A A. Dermatitis due to benzocaine present in sunscreens containing glyceryl PABA (Escalol 106). Contact Dermatitis 1977: 3: 170–171. 3 Lewis F M, Harrington C I, Gawkrodger D J. Contact sensitivity in pruritus vulvae: a common and manageable problem. 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