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Experimental autoimmune uveoretinitis (EAU) induced by retinal interphotoreceptor retinoid-binding protein (IRBP): Differences between EAU induced by IRBP and by S-antigen

1987; Academic Press; Volume: 43; Issue: 2 Linguagem: Inglês

10.1016/0090-1229(87)90133-4

1090-2341

Gregory M. Fox, Toichiro Kuwabara, Barbara Wiggert, T. Michael Redmond, Helen H. Hess, Gerald J. Chader, Igal Gery,

Systemic Lupus Erythematosus Research

Rats immunized with the retinal interphotoreceptor retinoid-binding protein (IRBP) develop an inflammatory eye disease, "experimental autoimmune uveoretinitis" (EAU). The ocular changes which characterize the EAU induced by IRBP resemble those seen in rats which develop EAU by immunization with another retinal protein, S-antigen (S-Ag). Yet, the two antigens do not cross-react antigenically and the two diseases differ by several features: (1) At low doses (≤4 μg/rat), IRBP was more uveitogenic in Lewis rats than was S-Ag, inducing disease more reproducibly and with earlier onset time. On the other hand, at higher doses (≥20 μg/rat) the disease induced by S-Ag was more severe than that induced by the same doses of IRBP. (2) Rats of various inbred strains differed in their susceptibility to EAU induced by these two antigens. In particular, BN rats were more susceptible to IRBP-induced EAU than to the S-Ag-induced disease, while WF and RCS-rdy+ rats developed severe EAU when immunized with S-Ag but showed minimal or no ocular change when immunized with IRBP.