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Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics

2009; Elsevier BV; Volume: 34; Issue: 1 Linguagem: Inglês

10.1016/j.nbd.2008.12.008

1095-953X

Walter Maetzler, Inga Liepelt, Matthias Reimold, Gerald Reischl, Christoph Solbach, Clemens Becker, Claudia Schulte, Thomas Leyhe, Stefanie Keller, Arthur Melms, Thomas Gasser, Daniela Berg,

Parkinson's Disease Mechanisms and Treatments

About one fourth of Lewy body disease (LBD) patients show cortical beta-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [11C]PIB-PET, we tested whether LBD patients with beta-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters. Thirty-five LBD subjects (9 patients with Lewy body dementia, DLB; 12 demented Parkinson patients, PDD; 14 non-demented PD, PDND) underwent [11C]PIB-PET, and were classified as either PIB(+) or PIB(-) according to cortical PIB uptake. PIB+ and PIB(-) patients were then compared according to demographic, clinical, biochemical and genetic parameters. None of the PDND, but four PDD and four DLB subjects were PIB+. In PIB+ subjects, ApoE4 prevalence was higher, CSF Abeta42 levels were lower and, among demented patients, PIB-binding was associated with a lower MMSE score. Motor symptoms were not associated with PIB binding. Thus, LBD patients with cortical beta-amyloid show characteristics usually observed in AD.