Vascular-targeted photodynamic therapy with TOOKAD® Soluble in localized prostate cancer: standardization of the procedure
2015; Springer Science+Business Media; Volume: 33; Issue: 7 Linguagem: Inglês
10.1007/s00345-015-1535-2
ISSN1433-8726
AutoresAbdel-Rahmène Azzouzi, Souhil Lebdai, Fawzi Benzaghou, Christian G. Stief,
Tópico(s)Photoacoustic and Ultrasonic Imaging
ResumoVascular-targeted photodynamic therapy with TOOKAD(®) Soluble is an innovative focal therapy procedure assessed in localized prostate cancer treatment.This mini-invasive technique destroys targeted tissues using a photosensitizer [TOOKAD(®) Soluble (WST11), STEBA Biotech] activated by laser light in the presence of oxygen. Its application for prostate cancer requires intravenous infusion of TOOKAD(®) Soluble and the illumination of the targeted area by transperineal optical fibers inserted under trans-rectal ultrasound guidance under general anesthesia.Based on the experience gained through hundreds of procedures, we describe here the standardized technique of vascular-targeted photodynamic therapy with TOOKAD(®) Soluble defined during the phase II and III trials.
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