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The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells

2014; American Association for the Advancement of Science; Volume: 7; Issue: 317 Linguagem: Inglês

10.1126/scisignal.2004545

1937-9145

Anne-Solen Geimer Le Lay, Attila Oravecz, Jérôme Mastio, Claudia Jung, Patricia Marchal, Claudine Ebel, Doulaye Dembélé, Bernard Jost, Stéphanie Le Gras, Christelle Thibault-Carpentier, Tilman Borggrefe, Philippe Kastner, Susan Chan,

Epigenetics and DNA Methylation

By binding to Notch target genes, Ikaros shuts off the expression of these genes in T cells and prevents the development of T cell acute lymphoblastic leukemia.