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Pirenzepine in Erosive Duodenitis

1985; Taylor & Francis; Volume: 20; Issue: 6 Linguagem: Inglês

10.3109/00365528509089207

1502-7708

Mario Guslandi, S. Daniotti, Elena Ballarín, M. Basilico, A. Tittobello,

Inflammatory mediators and NSAID effects

Fifty-five outpatients with chronic duodenal erosions and no previous ulcer history were treated, in a double-blind fashion, with either pirenzepine (50 mg twice daily) or ranitidine (150 mg twice daily) for 6 weeks. The drugs were equally effective in inducing symptomatic relief. At endoscopic control, 70.4% of subjects in the pirenzepine group and 39.3% of ranitidine-treated patients showed complete healing (p < 0.05). The results suggest that acid secretion is not an important factor in the pathogenesis of erosive duodenitis and that other mechanisms (such as impaired mucosal blood flow) must be considered.