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Renal Mass Biopsy—A Renaissance?

2007; Lippincott Williams & Wilkins; Volume: 179; Issue: 1 Linguagem: Inglês

10.1016/j.juro.2007.08.124

1527-3792

Brian R. Lane, Mary K. Samplaski, Brian R. Herts, Ming Zhou, Andrew C. Novick, Steven C. Campbell,

Renal Diseases and Glomerulopathies

No AccessJournal of UrologyReview article1 Jan 2008Renal Mass Biopsy—A Renaissance? Brian R. Lane, Mary K. Samplaski, Brian R. Herts, Ming Zhou, Andrew C. Novick, and Steven C. Campbell Brian R. LaneBrian R. Lane Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author , Mary K. SamplaskiMary K. Samplaski Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author , Brian R. HertsBrian R. Herts Department of Radiology, Cleveland Clinic, Cleveland, Ohio More articles by this author , Ming ZhouMing Zhou Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio More articles by this author , Andrew C. NovickAndrew C. Novick Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author , and Steven C. CampbellSteven C. Campbell Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.08.124AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Advances in our understanding of the natural history and limited aggressive potential of many small renal masses, expanding treatment options and the integration of molecular factors into prognostic and therapeutic algorithms have stimulated renewed interest in percutaneous renal mass biopsy. Materials and Methods: A comprehensive literature review was performed using MEDLINE®/PubMed® to evaluate the indications, techniques, complications and efficacy of renal mass biopsy. Results: Reported techniques of renal mass biopsy vary widely with different modes of radiographic guidance, needle size, number of cores and pathological analyses. Percutaneous renal mass biopsy with 2 or 3 cores using 18 gauge needles may improve diagnostic accuracy without increasing morbidity. Serious complications of percutaneous biopsy are rare and the minor complication rate in recent series has been less than 5%. The reported rate of technical failure of renal mass biopsy due to insufficient material was about 9% before 2001 and 5% in more recent studies. The likelihood of indeterminate or inaccurate pathological findings has decreased from 10% to 4% when comparing clinical studies before and since 2001. Currently a total success rate of greater than 90% is attainable using renal mass biopsy with standard histopathological analysis. Recent studies demonstrated that combining immunohistochemical and molecular analyses may further improve renal mass biopsy accuracy. Conclusions: Research on expanded analysis of percutaneous renal mass biopsy specimens should remain a top priority. 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Volume 179Issue 1January 2008Page: 20-27 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordskidneycarcinomarenal cellbiopsyepidemiologymoleculardiagnosisMetrics Author Information Brian R. Lane Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Mary K. Samplaski Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Brian R. Herts Department of Radiology, Cleveland Clinic, Cleveland, Ohio More articles by this author Ming Zhou Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio More articles by this author Andrew C. Novick Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Steven C. Campbell Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Expand All Advertisement PDF downloadLoading ...