Distribution of GABA in the periaqueductal gray matter. Effects of medial hypothalamic lesions
1981; Elsevier BV; Volume: 224; Issue: 2 Linguagem: Inglês
10.1016/0006-8993(81)90859-3
ISSN1872-6240
AutoresGuy Sandner, Daniel Dessort, Pierre Schmitt, Pierre Karli,
Tópico(s)Olfactory and Sensory Function Studies
ResumoGas chromatography and chemical ionization mass spectrometry were used in order to measure the GABA (γ-aminobutyric acid) concentration in a series of successive horizontal slices of the mesencephalic periaqueductal gray (CG) as well as in a series of successive frontal CG slices in the rat. Along the dorso-ventral axis, the GABA concentration (3.5–7 μg/mg protein) was found first to increase and then to decrease, a maximum concentration being found at the level of the aqueduct. In contrast, no concentration gradient was found along the caudo-rostral axis. In an additional experiment, the medial hypothalamus (MH) was lesioned on one side and the effect of such a unilateral MH lesion on the caudo-rostral distribution of GABA was investigated. Fifteen days after performing the lesion, a graded decrease in GABA concentration — with a maximum in the rostral CG — was found to occur mainly on the lesioned side.
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