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Lateral Hypothalamus Modulates the Intrinsic Splenic Natural Killer Cell Activity in Rats

1998; Karger Publishers; Volume: 5; Issue: 5 Linguagem: Inglês

10.1159/000026341

1423-0216

Hirofumi Iimori, Noriyuki Kawamura, Marcus Wenner, Masato Murakami, Hiroshi Yamamoto,

Neurogenesis and neuroplasticity mechanisms

Electrical stimulation of the lateral hypothalamus (LH) in rats increased splenic natural killer (NK) cell activity, whereas electrical ablation of the LH decreased it. However, the percentage of NK cells, as detected by the anti-NKR-P1 monoclonal antibody, in the spleen did not change significantly. These results suggest that the LH does not modulate the splenic NK cell activity by increasing the NK cell number but by increasing the intrinsic NK cell activity itself.