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I3-naringenin-II8-4′-OMe-eriodictyol: a New Potential Analgesie Agent Isolated from Rheedia gardneriana Leaves

2000; De Gruyter; Volume: 55; Issue: 9-10 Linguagem: Inglês

10.1515/znc-2000-9-1024

1865-7125

Valdir Cechinel Filho, Karina L. da Silva, Márcia María de Souza, Ana Elisa Oliveira, Rosendo Augusto Yunes, Cláudio L. Guimarães, Luiz Gonzaga Verdi, Edésio Luiz Simionatto, Franco Delle Monachè,

Natural product bioactivities and synthesis

This paper describes the isolation, identification and analgesic activity of a new biflavonoid from Rheedia gardneriana leaves, which correspond to I3-naringenin-II8-4'-OMe-eriodictyol (GB-2a-II-4'-OMe) (1), with a methoxyl group in position 4 of ring-II. Its structure was determined by spectroscopic data and confirmed by an alkaline hydrolysis. Its analgesic effect was evaluated in a writhing test and a formalin test in mice. It was found that this compound exhibits potent and dose-related analgesic action in both experimental models, with ID50's values of 4.5 micromol/kg against the writhing test and 8.2 and 6.8 micromol/kg against the first and second phase of the formalin test, respectively. It was several times more potent than some well-known analgesic drugs used as reference.