Produção Nacional
Revisado por pares
HOXB5 expression in oral squamous cell carcinoma
2011; UNIVERSIDADE DE SÃO PAULO; Volume: 19; Issue: 2 Linguagem: Inglês
10.1590/s1678-77572011000200008
ISSN1678-7765
AutoresRenata Tucci, Márcia Sampaio Campos, Luciana Fasanella Matizonkas-Antonio, Marcelo Doria Durazzo, Décio dos Santos Pinto Júnior, Fábio Daumas Nunes,
Tópico(s)dental development and anomalies
ResumoHuman HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer.The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics.RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verified by the chi-square and post-hoc t-test.HOXB5 was amplified in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically significant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade.HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.
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